Misalignment between evidence base and global burden of disease

While the greatest burden of disease is borne by low-and middle- income countries, these research areas may not be the focus of (or contributions) to systematic reviews, which are regarded as the highest levels of evidence.

Articles that support this problem:

Evaluation of intervention systematic reviews on chronic non-communicable diseases and lifestyle risk factors in low-middle income countries: meta-research

2025 : Bmc medical research methodology

Interventions that address interpersonal violence experienced by adolescents globally: a systematic review of reviews

2024 : Injury prevention