- Framework of problems / Transparent
- No registered or published protocol
- Interventions for reducing red blood cell transfusion in adults undergoing hip fracture surgery: an overview of systematic reviews
| Ref ID | 1033 |
| First Author | S.R. Lewis |
| Journal | COCHRANE DATABASE OF SYSTEMATIC REVIEWS |
| Year Of Publishing | 2023 |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249061/ |
| Keywords |
Cochrane Surgery Musculoskeletal Non-Cochrane reviews Low methodological quality |
| Problem(s) |
No registered or published protocol Low methodological (AMSTAR) quality Conflicts of interest or funding of included studies not assessed Reasons for excluding potentially eligible studies not provided Meta-analyses and forest plots presented without considering risk of bias / quality |
| Number of systematic reviews included | 26 |
| Summary of Findings | AMSTAR 2 summary for the 17 reviews evaluating tranexamic acid showed very low confidence in 10 of them (58.8%). None explained their selection of the study designs for inclusion and 13 (76.4%) did not report the availability of a protocol. Only 1 review reported on the sources of funding for the studies (5.8%) and 4 (23.5%) reviews assessed the potential impact of risk of bias in individual studies on the results of the meta-analysis or other evidence synthesis. For the 9 reviews on iron, none explained their selection of the study designs for inclusion, and only one review reported the funding sources from each included study. Of the six reviews in which meta‐analysis was performed, three reviews did not report an assessment of publication bias alongside their results. |
| Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Yes |
| Are the methods of the article described in enough detail to replicate the study? |