| Ref ID | 1043 |
| First Author | M.C. Menne |
| Journal | IRISH VETERINARY JOURNAL |
| Year Of Publishing | 2023 |
| URL | https://irishvetjournal.biomedcentral.com/articles/10.1186/s13620-023-00261-w |
| Keywords |
• Dentistry • Animal studies • Low methodological quality |
| Problem(s) |
• Single reviewer / lack of double checking • Lack of prespecification in eligibility criteria • Reasons for excluding potentially eligible studies not provided • Conflicts of interest or funding of included studies not assessed • Risk of bias not incorporated into conclusions of review • Low methodological (AMSTAR) quality |
| Article Type | Empirical |
| Article Subtype | Cross-sectional survey/Methodological systematic review |
| First Author Country | Germany |
| Checklists |
• AMSTAR 2 |
| Aim | To assess the methodological quality and overall confidence in systematic reviews indexed across Pubmed, Scopus and Web of Science up to July 2022, of research using laboratory animals as models published on dental topics since February 2010. Also to investigate the association between certain systematic review characteristics and adherence to the AMSTAR-2 checklist using linear regression analyses. |
| Level of Investigation | Analytical |
| Summary of Findings | From 190 included systematic reviews indexed across Pubmed, Scopus and Web of Science up to July 2022, of research using laboratory animals as models. Using AMSTAR 2 to assess the included systematic reviews, 133 (70.0%) were deemed critically low. The items of particular concern were: 1) lack of explanation of the selection of study designs for inclusion in the review (71.5%), 2) review authors not performing data extraction in duplicate (64.7%), 3) review authors not providing a list of excluded studies with justifications (64.2%), 4) no report on the sources of funding for the studies included in the review (98.9%), and 5) no account for the risk of bias in individual studies when interpreting/ discussing the results. Multivariable linear regression analysis showed that the adherence scores of AMSTAR-2 was significantly positively associated with publication year, journal impact factor (IF), topic, and the use of tools to assess risk of bias (RoB) of the systematic reviews. |
| Number of systematic reviews included | 190 |
| Number of eligible systematic reviews assessed | 842 |