| Ref ID | 131 |
| First Author | M. J. Page |
| Journal | BMJ OPEN |
| Year Of Publishing | 2016 |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853995/pdf/bmjopen-2016-011863.pdf |
| Keywords |
• Rheumatology • Multiplicity • Pre-specification |
| Problem(s) |
• Multiplicity of outcomes and lack of pre-specification for outcome reporting |
| Article Type | Empirical |
| Article Subtype | Meta-epidemiological analysis |
| First Author Country | Australia |
| Aim | To assess the presence and impact of multiplicity of effect estimates to systematic reviews with meta-analyses of rheumatoid arthritis or osteoarthritis published between January 2010 and 2012. |
| Level of Investigation | Analytical |
| Summary of Findings | From analysis of 31 included systematic review with meta-analyses. The estimated Potential Bias Index was 0.57 (95% CI 0.50 to 0.63), suggesting that trial effect estimates that were more favourable to the intervention were included in meta-analyses slightly more often than expected under a process consistent with random selection; however, the 95% confidence interval included the null hypothesis of no selective inclusion. Any potential selective inclusion did not have an important impact on the meta-analytic effects. |
| Number of systematic reviews included | 31 |
| Number of eligible systematic reviews assessed | 2590 |
| Treatment impacted | Yes |
| Treatment impacted description | |
| Interpretation impacted | No |
| Interpretation impacted description |