| Ref ID | 156 |
| First Author | R. Chou |
| Journal | ANNALS OF INTERNAL MEDICINE |
| Year Of Publishing | 2005 |
| URL | https://www.acpjournals.org/doi/full/10.7326/0003-4819-142-12_Part_2-200506211-00009 |
| Keywords |
• Harms |
| Problem(s) |
• Inclusion of observational / non-randomised studies • Selective reporting of harms / safety / adverse events / side effects • Reliance on randomised controlled trials for harms / safety data |
| Article Type | Non-systematic literature review |
| First Author Country | United States |
| Aim | To assess the reporting of harms in systematic reviews produced by the US Evidence-based Practice Center reports published between December 1998 and April 2004. |
| Level of Investigation | Descriptive |
| Summary of Findings | Of 96 Evidence-based Practice Center evidence reports published between December 1998 and April 2004, 71 addressed health care interventions associated with potential harms. Of these, 11 did not assess harms. Two of the 11 evaluated surgical interventions, and the other 9 evaluated pharmacologic interventions or approaches to diagnostic testing and disease management. Of the 60 remaining EPC reports, 34 included observational studies of adverse events. Quality of observational studies is difficult to uniformly assess due to differences in study design for harms data and data from these studies is often inappropriately combined. |
| Number of systematic reviews included | 96 |
| Number of eligible systematic reviews assessed | 96 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |