| Ref ID | 157 |
| First Author | A. G. Dunn |
| Journal | ANNALS OF INTERNAL MEDICINE |
| Year Of Publishing | 2014 |
| URL | https://pubmed.ncbi.nlm.nih.gov/25285542/ |
| Keywords |
• Immunology • Influence • Allegiance • Author • Risk of bias • Sponsorship bias |
| Problem(s) |
• Risk of bias not incorporated into conclusions of review • Financial conflicts of interest of review authors |
| Article Type | Empirical |
| Article Subtype | Inter-rater agreement study |
| First Author Country | Australia |
| Aim | To assess the correlation between presence of conflicts of interest of review authors and favourable/ not favourable conclusions of systematic reviews of neuraminidase inhibitors for influenza published between 2005 and 2014. |
| Level of Investigation | Descriptive |
| Summary of Findings | Data from 26 included systematic reviews of neuraminidase inhibitors for influenza published between 2005 and 2014 were subject to dual blind inter-agreement. Among assessments associated with a financial conflict of interest, 7 of 8 (88%) were classified as favourable, compared with 5 of 29 (17%) among those without a financial conflict of interest. Reviewers without financial conflicts of interest were more likely to include statements about the quality and validity of the primary studies (15 of 19; 79%) than those with financial conflicts of interest (1 of 7; 14%). |
| Number of systematic reviews included | 26 |
| Number of eligible systematic reviews assessed | 827 |
| Treatment impacted | Yes |
| Treatment impacted description | |
| Interpretation impacted | Yes |
| Interpretation impacted description | A correlative relationship was found indicating that conflicts of interest were associated with favourable review conclusions and failure to consider the quality/validity of included studies. |