Methodologic Assessment of the Systematic Reviews of Ophthalmic Adverse Drug Reactions Published in Ophthalmology Journals: A Systematic Review

Ref ID	236
First Author	A. Penedones
Journal	OPHTHALMIC RESEARCH
Year Of Publishing	2018
URL	https://www.karger.com/Article/Pdf/489932
Keywords	• Harms • Pharmacological • Ophthalmology • Pre-specification • Risk of bias • Low reporting quality • Protocols
Problem(s)	• Lack of prespecification in eligibility criteria • Reasons for excluding potentially eligible studies not provided • No registered or published protocol • No quality assessment undertaken or reported
Number of systematic reviews included	21
Summary of Findings	Of the 21 systematic reviews reporting ophthalmic adverse drug reactions, there were weak areas of AMSTAR 2 quality. Only 14% reported an a priori protocol; the methodological quality was assessed in 57% systematic reviews; 71% of systematic reviews did not explain their selection of the study designs for inclusion in the review. The list of excluded articles and reasons of exclusion was not described in 67% of systematic reviews.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results?	N/A
Are the methods of the article described in enough detail to replicate the study?	Yes