| Ref ID | 372 |
| First Author | R. Bender |
| Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
| Year Of Publishing | 2008 |
| URL | https://www.jclinepi.com/article/S0895-4356(08)00093-0/fulltext |
| Keywords |
• General medical • Subgroup • Multiplicity • Pre-specification |
| Problem(s) |
• Multiplicity of outcomes and lack of pre-specification for outcome reporting • Unplanned or unjustified subgroup or sensitivity analyses |
| Article Type | Non-systematic literature review |
| First Author Country | Germany |
| Aim | To outline multiplicity in systematic reviews, and present some examples from published reviews, including Cochrane reviews. The authors also discuss ways that each type of multiplicity can be mitigated. |
| Level of Investigation | Descriptive |
| Summary of Findings | The authors highlight and discuss six types of multiplicity that can occur in systematic review with reference to some published examples. Multiplicity can occur from: multiple outcomes; multiple groups, multiple time points; multiple effect measures; subgroup analyses and multiple looks at accumulating data. |
| Number of systematic reviews included | 7 |
| Number of eligible systematic reviews assessed | 7 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |