| Ref ID | 377 |
| First Author | R. Parsons |
| Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
| Year Of Publishing | 2019 |
| URL | https://www.jclinepi.com/article/S0895-4356(18)30816-3/pdf |
| Keywords |
• Harms • Protocols |
| Problem(s) |
• Selective reporting of harms / safety / adverse events / side effects |
| Article Type | Empirical |
| Article Subtype | Cross-sectional survey/Methodological systematic review |
| First Author Country | United Kingdom |
| Aim | To assess adverse events reporting bias in both protocol registration and published systematic reviews of health care interventions registered in PROSPERO published in 2017 or 2018. |
| Level of Investigation | Descriptive |
| Summary of Findings | Of the included review protocols of health care interventions in PROSPERO, only 38% listed adverse events as an outcome of interest. In a final cohort 146 published reviews 65% fully reported the adverse events outcome exactly as intended from the protocol. 8% of the reviews excluded the adverse effect outcome entirely. The remaining 27% at least partially reported adverse events or in some way changed the reporting of the outcomes. |
| Number of systematic reviews included | 1376 |
| Number of eligible systematic reviews assessed | 2032 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |