Clinical heterogeneity was a common problem in Cochrane reviews of physiotherapy and occupational therapy

Ref ID 381
First Author C. H. van den Ende
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2006
URL https://www.jclinepi.com/article/S0895-4356(06)00059-X/fulltext
Keywords • Physiotherapy
• Low reporting quality
• Multiplicity
• Cochrane
• Heterogeneity
• Pre-specification
Problem(s) • Inadequate analysis of heterogeneity
• Multiplicity of outcomes and lack of pre-specification for outcome reporting
• Poor execution of narrative synthesis
• Intervention not described / defined
Article Type Empirical
Article Subtype Cross-sectional survey/Methodological systematic review
First Author Country The Netherlands
Aim To assess methods to deal with the clinical heterogeneity of interventions and multiple outcome measures used in Cochrane reviews on physiotherapy and occupational therapy published up to 2004.
Level of Investigation Descriptive
Summary of Findings In 58% of included reviews, more than one intervention was evaluated. In 52% of the reviews no quantitative data synthesis was performed, and in 33% reviews neither quantitative nor qualitative synthesis was performed. The reasons for not conducting a quantitative data synthesis were clinical and/or statistical heterogeneity; insufficient data reported; too few included studies; and other methodologic reasons. In 21% of studies a qualitative data synthesis was performed, using five different methods. In many reviews outcomes such as ‘‘functional ability’’ or ‘‘pain’’ were not restricted to specific instruments, which meant that a large number of instruments were investigated.
Number of systematic reviews included 52
Number of eligible systematic reviews assessed 189
Treatment impacted No
Treatment impacted description
Interpretation impacted Not Applicable
Interpretation impacted description