Assessing the applicability of findings in systematic reviews of complex interventions can enhance the utility of reviews for decision making

Ref ID 391
First Author B. Burford
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2013
URL https://www.jclinepi.com/article/S0895-4356(13)00263-1/fulltext
Keywords • General medical
• External validity
Problem(s) • Inflexible methods to complex questions
• Ignores setting or context of included studies which limits review applicability
Number of systematic reviews included 3
Summary of Findings Discusses challenges and opportunities of ensuring applicability of systematic reviews using three published examples of reviews of complex interventions. Recommendations include: Better description of population characteristics in primary studies, interventions, Use of qualitative evidence syntheses and logic models to generate hypotheses regarding the effects of intervention variation; Planned subgroup analyses/meta-regression to explore interactions between intervention variants and effects; Summarize effect sizes across outcome categories using the ‘‘median of medians’’ approach or other approaches that do not require statistical pooling of data
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? N/A
Are the methods of the article described in enough detail to replicate the study? No