| Ref ID | 391 |
| First Author | B. Burford |
| Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
| Year Of Publishing | 2013 |
| URL | https://www.jclinepi.com/article/S0895-4356(13)00263-1/fulltext |
| Keywords |
• General medical • External validity |
| Problem(s) |
• Inflexible methods to complex questions • Ignores setting or context of included studies which limits review applicability |
| Article Type | Editorial |
| Article Subtype | Discussion piece |
| First Author Country | Australia |
| Aim | Discusses challenges and opportunities of ensuring applicability of systematic reviews using three published examples of reviews of complex interventions. |
| Level of Investigation | Descriptive |
| Summary of Findings | Discusses challenges and opportunities of ensuring applicability of systematic reviews using three published examples of reviews of complex interventions. Recommendations include: Better description of population characteristics in primary studies, interventions, Use of qualitative evidence syntheses and logic models to generate hypotheses regarding the effects of intervention variation; Planned subgroup analyses/meta-regression to explore interactions between intervention variants and effects; Summarize effect sizes across outcome categories using the ‘‘median of medians’’ approach or other approaches that do not require statistical pooling of data |
| Number of systematic reviews included | 3 |
| Number of eligible systematic reviews assessed | 3 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |