- Framework of problems / Rigorous
- Weaknesses identified in some Cochrane reviews
- The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews
| Ref ID | 545 |
| First Author | R. M. Turner |
| Journal | PLOS ONE |
| Year Of Publishing | 2013 |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609745/pdf/pone.0059202.pdf |
| Keywords |
• General medical • Cochrane • Power |
| Problem(s) |
• Weaknesses identified in some Cochrane reviews • Perpetuates citation of poor quality primary study data |
| Number of systematic reviews included | 14886 |
| Summary of Findings | In 70% of CDSR meta-analyses, all studies had less than 50% power to detect a 30% relative risk reduction, and only 17% of meta-analyses included at least two studies with at least 50% power to detect a relative risk reduction of 30%. |
| Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | No |
| Are the methods of the article described in enough detail to replicate the study? | Yes |