Risk of bias assessment of sequence generation: a study of 100 systematic reviews of trials

Ref ID 561
First Author F. Wuytack
Journal SYSTEMATIC REVIEWS
Year Of Publishing 2019
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323681/pdf/13643_2018_Article_924.pdf
Keywords • General medical
• Risk of bias
• Inference
• Cochrane
Problem(s) • Limited quality assessment or no risk of bias
• Flawed risk of bias undertaken
Article Type Empirical
Article Subtype Cross-sectional survey/Methodological systematic review
First Author Country Ireland
Aim To assess the consistency in the risk of bias assessment for sequence generation of randomised trials in 64 Cochrane and 36 non-Cochrane reviews in 2016-2017. Additionally to explore the reviewers’ judgement of the quality of evidence for the related outcomes
Level of Investigation Descriptive
Summary of Findings Just under half of non-Cochrane reviews did not conduct a risk of bias assessment. Only one in ten non-Cochrane reviews reported the reasons for ascribing trials with high risk of bias for sequence generation
Number of systematic reviews included 100
Number of eligible systematic reviews assessed 274
Treatment impacted No
Treatment impacted description
Interpretation impacted Not Applicable
Interpretation impacted description