| Ref ID | 669 |
| First Author | B.A.M.P. Besen |
| Journal | CRITICAL CARE |
| Year Of Publishing | 2017 |
| URL | http://dx.doi.org/10.1186/s13054-017-1804-0 |
| Keywords |
• Error • Nephrology |
| Problem(s) |
• Perpetuates citation of poor quality primary study data • Errors in study inclusion or omission of relevant studies |
| Article Type | Editorial |
| Article Subtype | Comment/letter |
| First Author Country | Brazil |
| Aim | To highlight issues with one systematic review which meta-analysed only single-centre studies finding a significant treatment effect from renal replacement therapy |
| Level of Investigation | Analytical |
| Summary of Findings | The authors of the editorial re-conducted the meta-analysis from the systematic review but also included multi-centre RCTs (which had been excluded by the review in question) and in contrast to the systematic review authors, found no significant treatment effect from renal replacement therapy. |
| Number of systematic reviews included | 1 |
| Number of eligible systematic reviews assessed | 1 |
| Treatment impacted | Yes |
| Treatment impacted description | |
| Interpretation impacted | Yes |
| Interpretation impacted description | The authors performed a random-effects meta-analysis excluding studies that were not related to the systematic review’s original inclusion criteria and with a subgroup analysis to investigate single center effects. When considering only multicenter trials, the point estimate is pulled to the null and the results are neutral. |