| Ref ID | 682 |
| First Author | G. Gartlehner |
| Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
| Year Of Publishing | 2019 |
| URL | https://dx.doi.org/10.1016/j.jclinepi.2018.10.009 |
| Keywords |
• General medical • Cochrane • Author • Error • Outcomes |
| Problem(s) |
• Following guidelines is no guarantee of a rigorous systematic review • Errors in effect estimate calculations or data synthesis • Data extraction errors and double counting |
| Article Type | Empirical |
| Article Subtype | Meta-epidemiological analysis |
| First Author Country | United States |
| Checklists |
• AMSTAR 2 |
| Aim | To assess the risk for random errors in dichotomous outcomes graded as high certainty of evidence from a random selection of Cochrane reviews. |
| Level of Investigation | Analytical |
| Summary of Findings | Over one-third (38%) of outcomes rated as high certainty of evidence based on GRADE had increased risks for type I or type II errors. Analysis of predictive factors increased risk of errors indicated that in the majority of cases investigators responsible for rating certainty of evidence did not adhere to current guidance, particularly around imprecision. |
| Number of systematic reviews included | 100 |
| Number of eligible systematic reviews assessed | 100 |