| Ref ID | 709 |
| First Author | C. Riva |
| Journal | BMJ EVIDENCE-BASED MEDICINE |
| Year Of Publishing | 2019 |
| URL | https://dx.doi.org/10.1136/bmjebm-2018-111119 |
| Keywords |
• Cochrane • General medical • Risk of bias • Disclosure • Subgroup |
| Problem(s) |
• Meta-analyses and forest plots presented without considering risk of bias / quality • Unplanned or unjustified subgroup or sensitivity analyses • Flawed risk of bias undertaken • Risk of bias not incorporated into conclusions of review • Financial conflicts of interest of review authors |
| Article Type | Editorial |
| Article Subtype | Comment/letter |
| First Author Country | Switzerland |
| Aim | A letter highlighting concerns about a Cochrane review of human papillomavirus published in 2018. Concerns were shared with Cochrane in June 2018 but not published in entirety until September 2018. |
| Level of Investigation | Descriptive |
| Summary of Findings | Concerns included: studies’ quality not properly assessed; post hoc subgroup analyses presented as randomised controlled trial results; reporting bias not acknowledged; selective reporting not taken into consideration; biased trial designs; unpublished data not included; conflict of interests in the authors’ group; included studies for interventions no longer marketed in the USA |
| Number of systematic reviews included | 1 |
| Number of eligible systematic reviews assessed | 1 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |