| Ref ID | 738 |
| First Author | J.Dretzke |
| Journal | SYSTEMATIC REVIEWS |
| Year Of Publishing | 2014 |
| URL | https://pubmed.ncbi.nlm.nih.gov/25466903/ |
| Keywords |
• Risk of bias • Heterogeneity • Cardiology • Prognostic |
| Problem(s) |
• Risk of bias not incorporated into conclusions of review • No quality assessment undertaken or reported • Inadequate analysis of heterogeneity • Perpetuates citation of poor quality primary study data |
| Article Type | Empirical |
| Article Subtype | Cross-sectional survey/Methodological systematic review |
| First Author Country | United Kingdom |
| Aim | To assess the methodological conduct of systematic reviews for ‘aspirin resistance’ (a potential prognostic factor) for future vascular events in patients on aspirin therapy for secondary prevention. |
| Level of Investigation | Descriptive |
| Summary of Findings | Across the 8 included systematic reviews addressing the same clinical question of aspirin resistance as a prognostic factor for future vascular events, there were considerable differences in the numbers of studies identified and overlap between included studies, which could only partially be explained by different study eligibility criteria. Incomplete reporting and differences in terminology within primary studies hampered study identification and selection process across reviews. Quality assessment was highly variable and only one systematic review considered a checklist for studies of prognostic questions. Only two of the eight systematic reviews used quality assessment to inform the discussion around their findings. |
| Number of systematic reviews included | 8 |
| Number of eligible systematic reviews assessed | 17 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |