| Ref ID | 752 |
| First Author | P.J.Horsey |
| Journal | EUROPEAN JOURNAL OF ANAESTHESIOLOGY |
| Year Of Publishing | 2002 |
| URL | https://pubmed.ncbi.nlm.nih.gov/12463381/ |
| Keywords |
• Team • Author • Harms • Cochrane • Influence • Emergency medicine • Stakeholder • Inference |
| Problem(s) |
• Incorrect interpretation or statistical inference error from meta-analysis • Lack of clinical expert/ stakeholder/ user perspective |
| Article Type | Editorial |
| Article Subtype | Discussion piece |
| First Author Country | United Kingdom |
| Aim | A discussion piece highlighting the publication and aftermath of a Cochrane review of albumin administration in critically ill patients published in 1998. |
| Level of Investigation | Descriptive |
| Summary of Findings | The discussion piece regarding the Cochrane review of albumin administration in critically ill patients published in 1998 reports that none of the authors had the medical expertise or experience necessary to allow appropriate inferences from the included trial data regarding mortality outcomes and definitions. As a result the author argues that the Cochrane review erroneously concluded that albumin administration killed more patients than it saves. "In the seven highest quality trials in the hypovolaemia category the pooled relative risk was 0.87 (CI 0.67–1.14) implying a tendency to benefit from albumin in contrast with the Cochrane review figures of 1.46 (0.97–2.2) implying the opposite." |
| Number of systematic reviews included | 1 |
| Number of eligible systematic reviews assessed | 1 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |