| Ref ID | 811 |
| First Author | P. Jia |
| Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
| Year Of Publishing | 2021 |
| URL | https://www.sciencedirect.com/science/article/pii/S0895435620311884 |
| Keywords |
• Statistical • Cochrane • Power |
| Problem(s) |
• Small number of trials in meta-analyses • Weaknesses identified in some Cochrane reviews |
| Article Type | Empirical |
| Article Subtype | Cross-sectional survey/Methodological systematic review |
| First Author Country | China |
| Aim | To assess the statistical power of meta-analyses of rare events from the Cochrane Database of Systematic Reviews from January 2003 to May 2018. |
| Level of Investigation | Analytical |
| Summary of Findings | From 4,177 meta-analyses from the Cochrane Database of Systematic Reviews from January 2003 to May 2018 (no. of systematic reviews not reported), only 11.81% of meta-analyses reached sufficient power. The median power to detect 10%, 30%, and 50% relative risk reduction were 0.06 (interquartile range [IQR]: 0.05 to 0.06), 0.08 (IQR: 0.06 to 0.15), and 0.17 (IQR: 0.10 to 0.42), respectively); the corresponding proportion of meta-analyses that reached sufficient power were 0.32%, 3.68%, and 11.81%. Meta-analyses incorporating data from more studies had higher probability to achieve a sufficient power (rate ratio = 2.49, 95% CI: 1.76, 3.52, P < 0.001). |
| Number of systematic reviews included | 4177 |
| Number of eligible systematic reviews assessed | 6781 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |