| Ref ID | 814 |
| First Author | E.M.H. Padrao |
| Journal | BRITISH JOURNAL OF ANAESTHESIA |
| Year Of Publishing | 2022 |
| URL | https://www.bjanaesthesia.org/article/S0007-0912(22)00064-2/fulltext |
| Keywords |
• COVID • Error • Statistical • Observational studies • Outcomes • Non-Cochrane reviews |
| Problem(s) |
• Errors in effect estimate calculations or data synthesis • Failure to define clinically meaningful outcomes • Inclusion of observational / non-randomised studies |
| Article Type | Editorial |
| Article Subtype | Comment/letter |
| First Author Country | United States |
| Aim | A letter highlighting concerns with the conduct of one systematic review and meta-analysis of prone positioning in non-intubated spontaneously breathing patients in patients with COVID-19 published in 2022. |
| Level of Investigation | Analytical |
| Summary of Findings | The authors of the letter highlight concerns with the conduct of one systematic review and meta-analysis of prone positioning in non-intubated spontaneously breathing patients in patients with COVID-19 published in 2022. These include the questionable choice of outcome and outcome measurement used in the systematic review and the use of unadjusted results from observational studies in the pooled analysis. The letter authors perform an adjusted analysis of the systematic review using only studies which adjusted for confounding which the letter authors argue leads to a more precise estimate of efficacy than the original review. |
| Number of systematic reviews included | 1 |
| Number of eligible systematic reviews assessed | 1 |
| Treatment impacted | Yes |
| Treatment impacted description | The letter authors perform an adjusted analysis of the systematic review using only studies which adjusted for confounding which the letter authors argue leads to a different estimate of efficacy than the original review. |
| Interpretation impacted | No |
| Interpretation impacted description |