Results from a meta-analysis comparing bovine carotid artery grafts with polytetrafluoroethylene grafts must be interpreted with caution due to methodological flaws

Ref ID 828
First Author J.J. Ng
Journal JOURNAL OF VASCULAR ACCESS
Year Of Publishing 2021
URL https://journals.sagepub.com/doi/full/10.1177/1129729820946196?casa_token=9Fb9cm3qm9AAAAAA:EDGmGWwCM5JJkRnwZ0XjghvjdrP8Ek0tjkbesE9B8f_GP3l9enIc4vtgqCYnGrqN2cvHFHNMVgTsoQ
Keywords • Power
• Observational studies
• Heterogeneity
• Statistical
• Surgery
Problem(s) • Inclusion of observational / non-randomised studies
• Inadequate analysis of heterogeneity
• Lack of statistical expertise in handling of quantitative data
Article Type Editorial
Article Subtype Comment/letter
First Author Country Singapore
Aim A letter to the editor highlighting concerns with the conduct of a systematic review and meta-analysis published in 2020 of complication rates and patency outcomes of bovine carotid artery grafts with polytetrafluoroethylene grafts for haemodialysis vascular access.
Level of Investigation Descriptive
Summary of Findings The letter to the editor highlights concerns with the conduct of a systematic review and meta-analysis published in 2020 of complication rates and patency outcomes of bovine carotid artery grafts with polytetrafluoroethylene grafts for haemodialysis vascular access including the meta-analysis of one RCT with 3 observational studies resulting in considerable methodological, clinical and statistical heterogeneity.
Number of systematic reviews included 1
Number of eligible systematic reviews assessed 1
Treatment impacted No
Treatment impacted description
Interpretation impacted Not Applicable
Interpretation impacted description