| Ref ID | 862 |
| First Author | J. Deng |
| Journal | REVIEWS IN MEDICAL VIROLOGY |
| Year Of Publishing | 2022 |
| URL | https://onlinelibrary.wiley.com/doi/10.1002/rmv.2317 |
| Keywords |
• Certainty • Retraction • Non-Cochrane reviews • Expertise • Pre-specification • Risk of bias • Low reporting quality • Subgroup • Statistical • Pharmacological • Protocols • COVID |
| Problem(s) |
• Perpetuates citation of poor quality primary study data • Interpreted without considering certainty or overall quality of the evidence base • Undocumented or unjustified deviations to the review protocol • Unplanned or unjustified subgroup or sensitivity analyses • Lack of statistical expertise in handling of quantitative data • Flawed risk of bias undertaken • Low reporting or methodological quality (OTHER GUIDANCE) |
| Article Type | Editorial |
| Article Subtype | Comment/letter |
| First Author Country | Canada |
| Aim | A letter highlighting several limitations in the methodology and conduct of a systematic review on the efficacy of ivermectin treatment in COVID-19 patients. |
| Level of Investigation | Descriptive |
| Summary of Findings | From a letter highlighting several limitations in the methodology and conduct of a systematic review on the efficacy of ivermectin treatment in COVID-19 patients published in 2021. The author of the letter highlighted several areas of concern: lack of clarity about whether the Jadad tool was utilized correctly or provided a valid assessment to measure risk of bias in studies; no GRADE assessment on the confidence of their findings as required by PRISMA; tests were not perfomed for normality using established methods prior to proceeding with the imputation; some outcomes and subgroup analyses were not outlined on the PROSPERO registration; 9 out of 18 of the included studies were pre-print articles and included retracted studies. |
| Number of systematic reviews included | 1 |
| Number of eligible systematic reviews assessed | 1 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |