| Ref ID | 886 |
| First Author | T. Lu |
| Journal | JOURNAL OF ETHNOPHARMACOLOGY |
| Year Of Publishing | 2023 |
| URL | https://www.sciencedirect.com/science/article/pii/S0378874122008534?via%3Dihub |
| Keywords |
• Risk of bias • Low methodological quality • Oncology • Disclosure • Pre-specification • Complementary & Alternative |
| Problem(s) |
• Meta-analyses and forest plots presented without considering risk of bias / quality • Lack of prespecification in eligibility criteria • Reasons for excluding potentially eligible studies not provided • Conflicts of interest or funding of included studies not assessed • No registered or published protocol • Risk of bias not incorporated into conclusions of review |
| Article Type | Empirical |
| Article Subtype | Cross-sectional survey/Methodological systematic review |
| First Author Country | China |
| Checklists |
• AMSTAR 2 |
| Aim | To provide an evidence-based endorsement for the clinical application and selection of Kanglaite injection (KLTi) for non-small-cell lung cancer by evaluating the reporting quality, methodological quality, risk of bias, and evidence quality of systemic reviews. |
| Level of Investigation | Descriptive |
| Summary of Findings | From 20 included systematic reviews of Kanglaite injection (KLTi) for non-small-cell lung cancer indexed across 12 databases up to March 24 2022. The methodological quality of the methods used in all studies was critically low (AMSTAR 2). The most problematic items were: none of the researchers provided a list of excluded literature and their reasons; the authors did not explain the reasons for including the type of study design; they did not investigate the source of funding for the included studies; did not adequately discuss the potential impact of the risk of bias on the integration of meta-analyses. Only 2/20 systematic reviews reported having a protocol. |
| Number of systematic reviews included | 20 |
| Number of eligible systematic reviews assessed | 346 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |