Three out of four published systematic reviews on COVID-19 treatments were not registered and one-third of those registered were published: a meta-research study

Ref ID 910
First Author W. Siemens
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2022
URL https://www.sciencedirect.com/science/article/pii/S0895435622002323?via%3Dihub
Keywords • COVID
• Protocols
• Living
• Pre-specification
• Non-Cochrane reviews
Problem(s) • No registered or published protocol
Article Type Empirical
Article Subtype Cross-sectional survey/Methodological systematic review
First Author Country Germany
Aim The aim of this study is to describe (1) registered and (2) published systematic reviews (SRs) on COVID-19 treatments, and to analyze (3) the proportion of publications among registered SRs and (4) the proportion of registrations among published SRs.
Level of Investigation Analytical
Summary of Findings From 239 included systematic review of COVID-19 treatments registered in PROSPERO and in the COVID-19 Living Overview of the evidence ( https://app.iloveevidence.com). A total of 71 of 239 PROSPERO protocols (29.7%) were published as full systematic reviews. In the LĀ·OVE sample, 261 of 346 systematic reviews (75.4%) were not registered in PROSPERO before publication.
Number of systematic reviews included 239
Number of eligible systematic reviews assessed 595
Treatment impacted No
Treatment impacted description
Interpretation impacted Not Applicable
Interpretation impacted description