Systematic reviews of convalescent plasma in COVID-19 continue to be poorly conducted and reported: a systematic review

Ref ID 914
First Author R. Whear
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2022
URL https://www.sciencedirect.com/science/article/pii/S0895435622001780?via%3Dihub
Keywords • Overlapping reviews/redundancy
• COVID
• Low methodological quality
• Low reporting quality
• Non-Cochrane reviews
Problem(s) • Reasons for excluding potentially eligible studies not provided
• Conflicts of interest or funding of included studies not assessed
• Low reporting (PRISMA) quality
• Low methodological (AMSTAR) quality
• No registered or published protocol
• Redundant / overlapping / duplicated review question; leads to research waste
Article Type Empirical
Article Subtype Cross-sectional survey/Methodological systematic review
First Author Country United Kingdom
Aim To suggest possible approaches to combatting the impact of the COVID-19 infodemic to prevent research waste in future health emergencies and in everyday research and practice.
Level of Investigation Descriptive
Summary of Findings From 51 included systematic reviews of the effectiveness of convalescent plasma for COVID-19 indexed in the Epistemonikos database in June 2021. There was considerable duplication of effort; multiple reviews were conducted at the same time with inconsistencies in the evidence included. The reviews were of low methodological quality, poorly reported, and did not adhere to preferred reporting items for systematic reviews and meta-analysis guidance. The AMSTAR-2 items that were least reported were: no available protocol (69%), authors not providing a list of excluded studies and justify the exclusions (80%), and authors not reporting on the sources of funding for the studies included in the review (88%).
Number of systematic reviews included 51
Number of eligible systematic reviews assessed 102
Treatment impacted No
Treatment impacted description
Interpretation impacted Not Applicable
Interpretation impacted description