| Ref ID | 916 |
| First Author | S. Yousuf |
| Journal | JAC-ANTIMICROBIAL RESISTANCE |
| Year Of Publishing | 2023 |
| URL | https://academic.oup.com/jacamr/article/5/1/dlac127/6966941 |
| Keywords |
• Pre-specification • Disclosure • Low methodological quality • Outcomes • General medical |
| Problem(s) |
• Meta-analyses and forest plots presented without considering risk of bias / quality • Lack of prespecification in eligibility criteria • Reasons for excluding potentially eligible studies not provided • Funding or sponsor of systematic review not reported • Low methodological (AMSTAR) quality |
| Article Type | Empirical |
| Article Subtype | Cross-sectional survey/Methodological systematic review |
| First Author Country | United Kingdom |
| Checklists |
• AMSTAR 2 |
| Aim | To identify outcomes reported in systematic reviews of hospital antimicrobial stewardship interventions. |
| Level of Investigation | Descriptive |
| Summary of Findings | From 41 included systematic reviews of hospital antimicrobial stewardship interventions indexed across the Cochrane Database of Systematic Reviews, MEDLINE and Embase up to August 2019. There was significant heterogeneity in outcomes reported for hospital AMS interventions. Reported outcomes did not cover all domains of the COMET framework and may miss outcomes relevant to patients (e.g. emotional, social functioning, etc.). Of the 41 included studies, thirty-three (81%) systematic reviews were of critically low or low quality. The AMSTAR-2 items that were least reported were: authors explaining their selection of the study designs for inclusion in the review (12%); authors providing a list of excluded studies and justify the exclusions (36%); and authors not reporting on the sources of funding for the studies included in the review (24%) and authors assessing the potential impact of risk of bias in individual studies on the results of the meta-analysis (41%). |
| Number of systematic reviews included | 41 |
| Number of eligible systematic reviews assessed | 4903 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |