| Ref ID | 917 |
| First Author | C.C.W. Zhong |
| Journal | ALZHEIMER'S RESEARCH & THERAPY |
| Year Of Publishing | 2022 |
| URL | https://alzres.biomedcentral.com/articles/10.1186/s13195-022-01100-w |
| Keywords |
• Cochrane • Protocols • Neurology • Non-Cochrane reviews • Low methodological quality • Disclosure • Pre-specification • Cognition |
| Problem(s) |
• No registered or published protocol • Conflicts of interest or funding of included studies not assessed • Reasons for excluding potentially eligible studies not provided • Lack of prespecification in eligibility criteria • Low methodological (AMSTAR) quality |
| Article Type | Empirical |
| Article Subtype | Cross-sectional survey/Methodological systematic review |
| First Author Country | China |
| Checklists |
• AMSTAR 2 |
| Aim | To examine the methodological quality of Systematic Reviews on Alzheimer’s disease treatments, along with potentially relevant factors. |
| Level of Investigation | Descriptive |
| Summary of Findings | From 102 included systematic reviews of interventions for Alzheimer’s disease indexed across Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, and PsycINFO from January 2014 to February 2021. Of 102 reviews, the methodological quality (AMSTAR-2), 48 (47.1%), and 36 (35.3%) was low, and critically low quality, respectively. The following significant methodological limitations were identified: only 22.5% of systematic reviews registered protocols a priori, 6.9% discussed the rationales of chosen study designs, 21.6% gave a list of excluded studies with reasons, and 23.5% documented funding sources of primary studies. Cochrane systematic reviews (adjusted odds ratio (AOR): 31.9, 95% confidence interval (CI): 3.81–266.9) and systematic reviews of pharmacological treatments (AOR: 3.96, 95%CI: 1.27–12.3) were related to the higher overall methodological quality of systematic reviews. |
| Number of systematic reviews included | 102 |
| Number of eligible systematic reviews assessed | 8366 |
| Treatment impacted | No |
| Treatment impacted description | |
| Interpretation impacted | Not Applicable |
| Interpretation impacted description |