| Ref ID | 99 |
| First Author | C. Hansen |
| Journal | COCHRANE DATABASE OF SYSTEMATIC REVIEWS |
| Year Of Publishing | 2019 |
| URL | https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.MR000047.pub2/full |
| Keywords |
• Allegiance • Author • Cochrane • General medical |
| Problem(s) |
• Financial conflicts of interest of review authors |
| Article Type | Empirical |
| Article Subtype | Meta-epidemiological analysis |
| First Author Country | Denmark |
| Aim | To assess the degree to which financial conflicts of interest related to drug and device companies were associated with results, conclusions, and methodological quality of systematic reviews published across several databases up to November 2016. |
| Level of Investigation | Analytical |
| Summary of Findings | From ten studies of 1010 included systematic reviews. Systematic reviews with financial conflicts of interest more often had favourable conclusions compared with systematic reviews without (RR: 1.98, 95% CI: 1.26 to 3.11; based on seven studies of 411 systematic reviews). Similar results were found in two studies with a matched design, which therefore had a reduced risk of confounding. Systematic reviews with financial conflicts of interest tended to have lower methodological quality compared with systematic reviews without financial conflicts of interest (RR for 11 dimensions of methodological quality spanned from 1.00 to 1.83). Similar results were found in analyses based on two studies with matched designs. The estimated treatment effect was not statistically significantly different for systematic reviews with and without financial conflicts of interest (Z-score: 0.46, P value: 0.64; based on one study of 14 systematic reviews which had a matched design, comparing otherwise similar systematic reviews). |
| Number of systematic reviews included | 10 |
| Number of eligible systematic reviews assessed | 3494 |
| Treatment impacted | Yes |
| Treatment impacted description | |
| Interpretation impacted | No |
| Interpretation impacted description |