Reliance on randomised controlled trials for harms / safety data

Articles that support this problem:

Some improvements are apparent in identifying adverse effects in systematic reviews from 1994 to 2011

2013 : Journal of clinical epidemiology

Poor reporting and inadequate searches were apparent in systematic reviews of adverse effects

2008 : Journal of clinical epidemiology

Most systematic reviews of adverse effects did not include unpublished data

2016 : Journal of clinical epidemiology

Assessing harmful effects in systematic reviews

2004 : Bmc medical research methodology

Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses

2012 : Bmj

Challenges in systematic reviews that assess treatment harms

2005 : Annals of internal medicine

Availability of large-scale evidence on specific harms from systematic reviews of randomized trials

2004 : The american journal of medicine

The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias

2018 : Bmj evidence-based medicine

Selective reporting bias of harm outcomes within studies: findings from a cohort of systematic reviews

2014 : Bmj

Room for improvement? A survey of the methods used in systematic reviews of adverse effects

2006 : Bmc medical research methodology

Quality of reporting in systematic reviews of adverse events: systematic review

2014 : Bmj : british medical journal

Comparison of search strategies in systematic reviews of adverse effects to other systematic reviews

2014 : Health information & libraries journal