- Framework of problems /
- Small number of trials in meta-analyses
Articles that support this problem:
Systematic Reviews of Anesthesiologic Interventions Reported as Statistically Significant: Problems with Power, Precision, and Type 1 Error Protection
2015 : Anesthesia & analgesia
Reporting bias in the literature on the associations of health-related behaviors and statins with cardiovascular disease and all-cause mortality
2018 : Plos biology
Characteristics of meta-analyses and their component studies in the Cochrane Database of Systematic Reviews: a cross-sectional, descriptive analysis
2011 : Bmc medical research methodology
False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review
2016 : Bmj open
The knowledge system underpinning healthcare is not fit for purpose and must change
2015 : Bmj: british medical journal
Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered
2021 : Journal of clinical epidemiology