Small number of trials in meta-analyses

Articles that support this problem:

Systematic Reviews of Anesthesiologic Interventions Reported as Statistically Significant: Problems with Power, Precision, and Type 1 Error Protection

2015 : Anesthesia & analgesia

Reporting bias in the literature on the associations of health-related behaviors and statins with cardiovascular disease and all-cause mortality

2018 : Plos biology

Characteristics of meta-analyses and their component studies in the Cochrane Database of Systematic Reviews: a cross-sectional, descriptive analysis

2011 : Bmc medical research methodology

False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review

2016 : Bmj open

The knowledge system underpinning healthcare is not fit for purpose and must change

2015 : Bmj: british medical journal

Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered

2021 : Journal of clinical epidemiology