- Framework of problems / Transparent
- Multiplicity of outcomes and lack of pre-specification for outcome reporting
- Investigation of bias in meta-analyses due to selective inclusion of trial effect estimates: empirical study
| Ref ID | 131 |
| First Author | M. J. Page |
| Journal | BMJ OPEN |
| Year Of Publishing | 2016 |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853995/pdf/bmjopen-2016-011863.pdf |
| Keywords |
• Rheumatology • Multiplicity • Pre-specification |
| Problem(s) |
• Multiplicity of outcomes and lack of pre-specification for outcome reporting |
| Number of systematic reviews included | 31 |
| Summary of Findings | From analysis of 31 included systematic review with meta-analyses. The estimated Potential Bias Index was 0.57 (95% CI 0.50 to 0.63), suggesting that trial effect estimates that were more favourable to the intervention were included in meta-analyses slightly more often than expected under a process consistent with random selection; however, the 95% confidence interval included the null hypothesis of no selective inclusion. Any potential selective inclusion did not have an important impact on the meta-analytic effects. |
| Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | No |
| Are the methods of the article described in enough detail to replicate the study? | Yes |