- Framework of problems / Rigourous
- Flawed risk of bias undertaken
- In Cochrane reviews, risk of bias assessments for allocation concealment were frequently not in line with Cochrane's Handbook guidance
Ref ID | 346 |
First Author | I. Propadalo |
Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
Year Of Publishing | 2019 |
URL | https://www.jclinepi.com/article/S0895-4356(18)30625-5/fulltext |
Keywords |
Cochrane Risk of bias General medical |
Problem(s) |
Flawed risk of bias undertaken Weaknesses identified in some Cochrane reviews |
Number of systematic reviews included | 721 |
Summary of Findings | One-third (29%) of risk of bias judgments about allocation concealment in Cochrane reviews were discrepant from the Cochrane Handbook recommendations. Most discrepancies were made for trials where risk of bias was judged as low (92%). Cochrane authors used 66 categories of comments describing envelopes as a method of allocation concealment. In 66 envelope-related categories, describing risk of bias assessments from 15% of the analysed RCTs, most of the judgments were rated as low risk of bias, although only one of those categories is associated with low risk of bias according to the Cochrane Handbook. |
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Not Applicable |
Are the methods of the article described in enough detail to replicate the study? | Yes |