- Framework of problems / Rigourous
- Unplanned or unjustified subgroup or sensitivity analyses
- Attention should be given to multiplicity issues in systematic reviews
|JOURNAL OF CLINICAL EPIDEMIOLOGY
|Year Of Publishing
Multiplicity of outcomes and lack of pre-specification for outcome reporting
Unplanned or unjustified subgroup or sensitivity analyses
|Number of systematic reviews included
|Summary of Findings
|The authors highlight and discuss six types of multiplicity that can occur in systematic review with reference to some published examples. Multiplicity can occur from: multiple outcomes; multiple groups, multiple time points; multiple effect measures; subgroup analyses and multiple looks at accumulating data.
|Did the article find that the problem(s) led to qualitative changes in interpretation of the results?
|Are the methods of the article described in enough detail to replicate the study?