- Framework of problems / Rigourous
- Unplanned or unjustified subgroup or sensitivity analyses
- Attention should be given to multiplicity issues in systematic reviews
| Ref ID | 372 |
| First Author | R. Bender |
| Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
| Year Of Publishing | 2008 |
| URL | https://www.jclinepi.com/article/S0895-4356(08)00093-0/fulltext |
| Keywords |
Multiplicity Pre-specification Subgroup General medical |
| Problem(s) |
Multiplicity of outcomes and lack of pre-specification for outcome reporting Unplanned or unjustified subgroup or sensitivity analyses |
| Number of systematic reviews included | 7 |
| Summary of Findings | The authors highlight and discuss six types of multiplicity that can occur in systematic review with reference to some published examples. Multiplicity can occur from: multiple outcomes; multiple groups, multiple time points; multiple effect measures; subgroup analyses and multiple looks at accumulating data. |
| Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Not Applicable |
| Are the methods of the article described in enough detail to replicate the study? |