Most systematic reviews of adverse effects did not include unpublished data

Ref ID 374
First Author S. Golder
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2016
URL https://www.jclinepi.com/article/S0895-4356(16)30135-4/fulltext
Keywords • Grey literature
• General medical
Problem(s) • Grey literature excluded
• Reliance on randomised controlled trials for harms / safety data
Number of systematic reviews included 348
Summary of Findings Only 39% of all the included reviews searched a specific source for unpublished data, such as conference abstracts or trial registries, and nearly half of these reviews (48%) included unpublished data. Overall, 22% of reviews included unpublished data/studies
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? N/A
Are the methods of the article described in enough detail to replicate the study? No