|JOURNAL OF CLINICAL EPIDEMIOLOGY
|Year Of Publishing
Ignores setting or context of included studies which limits review applicability
Inflexible methods to complex questions
|Number of systematic reviews included
|Summary of Findings
|Discusses challenges and opportunities of ensuring applicability of systematic reviews using three published examples of reviews of complex interventions. Recommendations include: Better description of population characteristics in primary studies, interventions, Use of qualitative evidence syntheses and logic models to generate hypotheses regarding the effects of intervention variation; Planned subgroup analyses/meta-regression to explore interactions between intervention variants and effects; Summarize effect sizes across outcome categories using the ‘‘median of medians’’ approach or other approaches that do not require statistical pooling of data
|Did the article find that the problem(s) led to qualitative changes in interpretation of the results?
|Are the methods of the article described in enough detail to replicate the study?