- Framework of problems / Comprehensive
- Ignores setting or context of included studies which limits review applicability
- The need to consider the wider agenda in systematic reviews and meta-analyses: breadth, timing, and depth of the evidence
| Ref ID | 493 |
| First Author | J. P. Ioannidis |
| Journal | BMJ |
| Year Of Publishing | 2010 |
| URL | https://pubmed.ncbi.nlm.nih.gov/20837576/ |
| Keywords |
Multiplicity Open data Pharmacological External validity Publication bias Pre-specification |
| Problem(s) |
Ignores setting or context of included studies which limits review applicability Overly stringent inclusion criteria affecting external validity Perpetuates citation of poor quality primary study data |
| Number of systematic reviews included | 34 |
| Summary of Findings | All systematic reviews dealt with a single indication (for either one agent or multiple agents) but none considered several indications. 188 relevant trials were identified for 42 indications-pairs. Only 5 compared head to head different anti-TNF agents, and another 32 trials compared an anti-TNF agent with one or more active comparators (only 4 published at time of writing). All other trials were comparisons against placebo or no treatment. Overall, the published trials represented only 34% of the total evidence (46% if ongoing trials were excluded). |
| Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Not Applicable |
| Are the methods of the article described in enough detail to replicate the study? | Yes |