Multivariate meta-analysis helps examine the impact of outcome reporting bias in Cochrane rheumatoid arthritis reviews

Ref ID 494
First Author G. Frosi
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2015
URL https://www.jclinepi.com/article/S0895-4356(14)00495-8/fulltext
Keywords Cochrane
Multiplicity
Pre-specification
Rheumatology
Problem(s) Multiplicity of outcomes and lack of pre-specification for outcome reporting
Number of systematic reviews included 21
Summary of Findings Outcome reporting bias was highly suspected 22% of the 1,118 evaluable outcomes from 155 assessable trials. Multivariate meta-analysis and univariate results sometimes differed importantly. The maximum change in treatment effect estimate between MVMA and univariate meta-analysis approach was found to be 176% for one of the outcome considered.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Yes
Are the methods of the article described in enough detail to replicate the study? Yes