- Framework of problems / Transparent
- Multiplicity of outcomes and lack of pre-specification for outcome reporting
- Multivariate meta-analysis helps examine the impact of outcome reporting bias in Cochrane rheumatoid arthritis reviews
| Ref ID | 494 |
| First Author | G. Frosi |
| Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
| Year Of Publishing | 2015 |
| URL | https://www.jclinepi.com/article/S0895-4356(14)00495-8/fulltext |
| Keywords |
• Cochrane • Multiplicity • Pre-specification • Rheumatology |
| Problem(s) |
• Multiplicity of outcomes and lack of pre-specification for outcome reporting |
| Number of systematic reviews included | 21 |
| Summary of Findings | Outcome reporting bias was highly suspected 22% of the 1,118 evaluable outcomes from 155 assessable trials. Multivariate meta-analysis and univariate results sometimes differed importantly. The maximum change in treatment effect estimate between MVMA and univariate meta-analysis approach was found to be 176% for one of the outcome considered. |
| Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Yes |
| Are the methods of the article described in enough detail to replicate the study? | Yes |