- Framework of problems / Transparent
- Multiplicity of outcomes and lack of pre-specification for outcome reporting
- Multivariate meta-analysis helps examine the impact of outcome reporting bias in Cochrane rheumatoid arthritis reviews
Ref ID | 494 |
First Author | G. Frosi |
Journal | JOURNAL OF CLINICAL EPIDEMIOLOGY |
Year Of Publishing | 2015 |
URL | https://www.jclinepi.com/article/S0895-4356(14)00495-8/fulltext |
Keywords |
Cochrane Multiplicity Pre-specification Rheumatology |
Problem(s) |
Multiplicity of outcomes and lack of pre-specification for outcome reporting |
Number of systematic reviews included | 21 |
Summary of Findings | Outcome reporting bias was highly suspected 22% of the 1,118 evaluable outcomes from 155 assessable trials. Multivariate meta-analysis and univariate results sometimes differed importantly. The maximum change in treatment effect estimate between MVMA and univariate meta-analysis approach was found to be 176% for one of the outcome considered. |
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Yes |
Are the methods of the article described in enough detail to replicate the study? | Yes |