Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses

Ref ID 514
First Author J. Brok
Journal INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Year Of Publishing 2009
URL https://watermark.silverchair.com/dyn188.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAApswggKXBgkqhkiG9w0BBwagggKIMIIChAIBADCCAn0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMuvz_lYbD73pT_woyAgEQgIICTniKbVTekrfmPTkyRnR84OhB8_G83t_HKYTKUSsZX4A1n5gtODlQMJsKxUMvA-LX7Ab64xUnwHHdIVMt1dRJxl7byQJSCHi01FXij2AyTXDy8mLjZnDbNbD2quwd3n-5SEh1KHAOApoHk8E-xGlE_hKiwwTlstK1QhuCTsUNW_tjmkWbGnA0LyKAp6dBeIq7CoyI5vDcL455766Z_HJMpEv6fbAMPL-WoL22eZ85Ikol9wXhlacPCMsmc6G-ycllhYzaMLSbXBr7B90E99c4M9TgfZZG-dCix7IxTYFXhPakW0FcX58ToHU2cuVABvsCgvzM2VLfz7tCk4xIYpaNrUk3uUQBt4PD2EFuTwNC6hlu1iRPMSHU6fJQObKJFDBHuk9XQJZnqArxBSxeVPCc05e5TSC_1IwLaqpfHBe3F2JUVKOeAkA799JV5diBxYSwXFt_dSSKMWRFy45xfLpgyBdkBhHa5Yf3DzDDzSe9I3KjZw290Ze3halEReXh6KjawvH2uOOR8j16U5DNtA7K9p6_vbnYr_zSZCfrkvPanmDyd76UeALbY-FxXZ2uxilyJhtatG98bdF9xFkUseShq9WKvspFf0hVgaGnvmSfDKBUWd6_3_6ZxiBNyi7qCox5JtGKOL0k1h5WiBrUWH7bxqgueNQmQjsBfDNjOnG3tqWPo8yGCSabhoQIyJ4w17x2FZOeV3vPIDdWgg3A0-V0khyHvzZwD-woE7UE4IXlnF9keEFheN_oL9llew-hiEd-6ya6VLISJsN5wrqJNrdH
Keywords Cochrane
Paediatrics
Heterogeneity
Problem(s) Inadequate analysis of heterogeneity
Perpetuates citation of poor quality primary study data
Number of systematic reviews included 21
Summary of Findings The accrued number of participants did not reach the required information size in 72% of meta-analyses required to accept or reject an intervention effect of 25% relative risk reduction. The median additional information size required to obtain evidence for or against 25% relative risk reduction in these meta-analyses was 1591 participants (range 339–6149).
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Yes
Are the methods of the article described in enough detail to replicate the study? Yes