Age-treatment subgroup analyses in Cochrane intervention reviews: a meta-epidemiological study

Ref ID 530
First Author P. Liu
Journal BMC MEDICINE
Year Of Publishing 2019
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805640/pdf/12916_2019_Article_1420.pdf
Keywords Cochrane
Multiplicity
Pre-specification
Subgroup
General medical
Problem(s) Unplanned or unjustified subgroup or sensitivity analyses
Multiplicity of outcomes and lack of pre-specification for outcome reporting
Number of systematic reviews included 928
Summary of Findings 20.4% of the 928 included Cochrane reviews outlined plans to conduct age treatment subgroup analyses. However, 2.7% reviews actually reported age-treatment subgroup analyses. Three reviews performed unplanned age-treatment subgroup analyses.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Not Applicable
Are the methods of the article described in enough detail to replicate the study? Yes