- Framework of problems / Comprehensive
- Grey literature excluded
- Impact of inclusion of industry trial results registries as an information source for systematic reviews
Ref ID | 551 |
First Author | R. Potthast |
Journal | PLOS ONE |
Year Of Publishing | 2014 |
URL | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092067 |
Keywords |
Harms Grey literature Pharmacological Publication bias Searching |
Problem(s) |
Lack of supplementary searches beyond databases Grey literature excluded |
Number of systematic reviews included | 150 |
Summary of Findings | In 23/150 reviews, relevant trials were missed from registries. In 6/23 reviews, inclusion of these omitted trials changed the treatment effect. In 17/23 reviews, the treatment effect was unchanged. Less than half of all the systematic reviews considered ClinicalTrials.gov as an information source. |
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Yes |
Are the methods of the article described in enough detail to replicate the study? | Yes |