Outcomes in systematic reviews of complex interventions never reached “high” GRADE ratings when compared with those of simple interventions

Ref ID 604
First Author A. Movsisyan
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2016
URL https://www.jclinepi.com/article/S0895-4356(16)30026-9/abstract
Keywords Imprecision
General medical
Problem(s) Inflexible methods to complex questions
Number of systematic reviews included 40
Summary of Findings The quality of evidence never reached ‘‘high’’ GRADE ratings for the outcomes of complex intervention reviews, compared to simple intervention reviews. Quality ratings were commonly downgraded in the Risk of Bias assessment, particularly for lack of participant and personnel blinding; high levels of heterogeneity, and the study design
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Not Applicable
Are the methods of the article described in enough detail to replicate the study? Yes