Increased risks for random errors are common in outcomes graded as high certainty of evidence

Ref ID 682
First Author G. Gartlehner
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2019
URL https://dx.doi.org/10.1016/j.jclinepi.2018.10.009
Keywords Cochrane
Author
Error
General medical
Outcomes
Problem(s) Following guidelines is no guarantee of a rigorous systematic review
Errors in effect estimate calculations or data synthesis
Data extraction errors and double counting
Number of systematic reviews included 100
Summary of Findings Over one-third (38%) of outcomes rated as high certainty of evidence based on GRADE had increased risks for type I or type II errors. Analysis of predictive factors increased risk of errors indicated that in the majority of cases investigators responsible for rating certainty of evidence did not adhere to current guidance, particularly around imprecision.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Not Applicable
Are the methods of the article described in enough detail to replicate the study? Yes