Risk of Bias and Quality of Reporting in Colon and Rectal Cancer Systematic Reviews Cited by National Comprehensive Cancer Network Guidelines

Ref ID	72
First Author	C. Wayant
Journal	JOURNAL OF GENERAL INTERNAL MEDICINE
Year Of Publishing	2020
URL	https://pubmed.ncbi.nlm.nih.gov/31950401/
Keywords	• Oncology • Protocols • Pre-specification
Problem(s)	• No registered or published protocol • Lack of prespecification in eligibility criteria • High risk of bias (ROBIS)
Number of systematic reviews included	63
Summary of Findings	Using ROBIS, only 3 (4.8%) of the included 63 systematic reviews were judged with low risk of bias, 35 (55.6%) systematic reviews were judged with unclear risk of bias, and 25 (39.7%) systematic reviews were judged with high risk of bias. Across all systematic reviews, the individual bias domains at the highest risk of bias were domains 1 (protocol and eligibility criteria) and 2 (methods to identify and select studies). Across all studies, the median adherence to PRISMA was 74.1% (IQR 69.2–80.0%), corresponding to approximately 20 of 27 items.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results?	N/A
Are the methods of the article described in enough detail to replicate the study?	Yes