Reporting of financial conflicts of interest in meta-analyses of drug trials published in high-impact medical journals: comparison of results from 2017 to 2018 and 2009

Ref ID 747
First Author C. Benea
Journal SYSTEMATIC REVIEWS
Year Of Publishing 2020
URL https://www.ncbi.nlm.nih.gov/pubmed/32268911
Keywords Cochrane
Allegiance
Disclosure
General medical
Non-Cochrane reviews
Problem(s) Conflict of interest statement or disclosures for review authors missing
Cochrane reviews more rigorous/higher quality than non-Cochrane reviews
Funding or sponsor of systematic review not reported
Number of systematic reviews included 29
Summary of Findings Reporting of drug trial sponsorship and author financial conflicts of interest in meta-analyses published in high-impact journals increased since 2009 but was still suboptimal. Among 29 meta-analyses reviewed, 13 of 29 (44.8%) reported the funding source of included trials compared to 2 of 29 (6.9%) in 2009, a difference of 37.9% (95% confidence interval, 15.7 to 56.3%); this included 7 of 11 (63.6%) from general medicine journals, 3 of 15 (20.0%) from specialty medicine journals, and 3 of 3 (100%) Cochrane reviews. Only 2 of 29 meta-analyses (6.9%) reported trial author financial conflicts of interest, and none reported trial author-industry employment.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Not Applicable
Are the methods of the article described in enough detail to replicate the study? Yes