Digital Biomarker-Based Interventions: Systematic Review of Systematic Reviews

Ref ID 892
First Author H. Motahari-Nezhad
Journal JOURNAL OF MEDICAL INTERNET RESEARCH
Year Of Publishing 2022
URL https://www.jmir.org/2022/12/e41042
Keywords Publication bias
Risk of bias
Disclosure
General medical
Low reporting quality
Searching
Low methodological quality
Problem(s) Low methodological (AMSTAR) quality
Risk of bias not incorporated into conclusions of review
Conflicts of interest or funding of included studies not assessed
Reasons for excluding potentially eligible studies not provided
Insufficient literature searches
Poor consideration of publication bias
Number of systematic reviews included 25
Summary of Findings From 25 included systematic reviews with meta-analyses of clinical outcomes (efficacy and safety endpoints) of digital biomarker–based interventions compared with alternative interventions without digital biomarkers indexed across PubMed and the Cochrane Library between 2019-2020. Most reviews (23/25, 92%) had critically low methodological quality according to the assessment using AMSTAR-2. From the 25 reviews 92% did not report a comprehensive literature search or provide a list of excluded studies or funding sources. Only 7 reviews (28%) took risk of bias into account when reporting results and 13 (52%) did not carry out an adequate investigation of publication bias.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Not Applicable
Are the methods of the article described in enough detail to replicate the study? Yes