Three out of four published systematic reviews on COVID-19 treatments were not registered and one-third of those registered were published: a meta-research study

Ref ID 910
First Author W. Siemens
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2022
URL https://www.sciencedirect.com/science/article/pii/S0895435622002323?via%3Dihub
Keywords Protocols
COVID
Pre-specification
Non-Cochrane reviews
Living
Problem(s) No registered or published protocol
Number of systematic reviews included 239
Summary of Findings From 239 included systematic review of COVID-19 treatments registered in PROSPERO and in the COVID-19 Living Overview of the evidence ( https://app.iloveevidence.com). A total of 71 of 239 PROSPERO protocols (29.7%) were published as full systematic reviews. In the L·OVE sample, 261 of 346 systematic reviews (75.4%) were not registered in PROSPERO before publication.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Not Applicable
Are the methods of the article described in enough detail to replicate the study? Yes