More than one-third of systematic reviews did not fully report the adverse events outcome

Ref ID 377
First Author R. Parsons
Journal JOURNAL OF CLINICAL EPIDEMIOLOGY
Year Of Publishing 2019
URL https://www.jclinepi.com/article/S0895-4356(18)30816-3/pdf
Keywords Harms
Protocols
Problem(s) Selective reporting of harms / safety / adverse events / side effects
Number of systematic reviews included 1376
Summary of Findings Of the included review protocols of health care interventions in PROSPERO, only 38% listed adverse events as an outcome of interest. In a final cohort 146 published reviews 65% fully reported the adverse events outcome exactly as intended from the protocol. 8% of the reviews excluded the adverse effect outcome entirely. The remaining 27% at least partially reported adverse events or in some way changed the reporting of the outcomes.
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? Not Applicable
Are the methods of the article described in enough detail to replicate the study? Yes