- Framework of problems / Transparent
- Selective reporting of harms / safety / adverse events / side effects
- The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias
|BMJ EVIDENCE-BASED MEDICINE
|Year Of Publishing
Risk of bias
Low reporting quality
Financial conflicts of interest of review authors
Errors in study inclusion or omission of relevant studies
Overly stringent inclusion criteria affecting external validity
Conflicts of interest or funding of included studies not assessed
Non-financial conflicts of interest of review authors
Flawed risk of bias undertaken
Weaknesses identified in some Cochrane reviews
Reliance on randomised controlled trials for harms / safety data
Selective reporting of harms / safety / adverse events / side effects
Individual study characteristics not reported sufficiently
|Number of systematic reviews included
|Summary of Findings
|The authors highlight several concerns including omission of relevant trials, omission of searching clinical trial registries, inaccurate classification of the comparator in included trials, trial inclusion criteria which limited the external validity of the conclusions, omission of some adverse event data, flawed risk of bias which judged reporting bias of included trials as low, failure to adequately assess conflicts of interest of included studies, conflicts of interest of review authors.
|Did the article find that the problem(s) led to qualitative changes in interpretation of the results?
|Are the methods of the article described in enough detail to replicate the study?