- Framework of problems / Transparent
- Selective reporting of harms / safety / adverse events / side effects
- Availability of large-scale evidence on specific harms from systematic reviews of randomized trials
Ref ID | 651 |
First Author | P. N. Papanikolaou |
Journal | THE AMERICAN JOURNAL OF MEDICINE |
Year Of Publishing | 2004 |
URL | https://www.amjmed.com/article/S0002-9343(04)00494-2/fulltext |
Keywords |
Cochrane Harms Open data |
Problem(s) |
Selective reporting of harms / safety / adverse events / side effects Reliance on randomised controlled trials for harms / safety data Weaknesses identified in some Cochrane reviews |
Number of systematic reviews included | 138 |
Summary of Findings | Systematic reviews of randomized controlled trials rarely provide large-scale evidence on specific, well-defined adverse events associated with the tested interventions. Only 25 systematic reviews in the entire Cochrane Database of Systematic Reviews contained such evidence on at least one type of harm. |
Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Yes |
Are the methods of the article described in enough detail to replicate the study? | Yes |