- Framework of problems / Transparent
- Selective reporting of harms / safety / adverse events / side effects
- Availability of large-scale evidence on specific harms from systematic reviews of randomized trials
| Ref ID | 651 |
| First Author | P. N. Papanikolaou |
| Journal | THE AMERICAN JOURNAL OF MEDICINE |
| Year Of Publishing | 2004 |
| URL | https://www.amjmed.com/article/S0002-9343(04)00494-2/fulltext |
| Keywords |
• Cochrane • Harms • Open data |
| Problem(s) |
• Selective reporting of harms / safety / adverse events / side effects • Reliance on randomised controlled trials for harms / safety data • Weaknesses identified in some Cochrane reviews |
| Number of systematic reviews included | 138 |
| Summary of Findings | Systematic reviews of randomized controlled trials rarely provide large-scale evidence on specific, well-defined adverse events associated with the tested interventions. Only 25 systematic reviews in the entire Cochrane Database of Systematic Reviews contained such evidence on at least one type of harm. |
| Did the article find that the problem(s) led to qualitative changes in interpretation of the results? | Yes |
| Are the methods of the article described in enough detail to replicate the study? | Yes |